BPC-157
Molecular Research Profile ยท Target purity > 99.2% ยท Half-life Short (~4 hours systemic)
Body Protection Compound 157. Renowned for accelerating tendon, ligament, gut-lining, and soft tissue repair via angiogenic pathways.
BPC-157 Molecular Formula, Structure & Chemical Identity
Reference identifiers researchers use to verify that a vial matches what a vendor claims to have shipped. Cross-check these values against any Certificate of Analysis before accepting a purity figure.
| Molecular Formula | C62H98N16O22 |
|---|---|
| Molecular Weight | 1419.6 g/mol |
| CAS Number | 137525-51-0 |
| Amino Acid Count | 15 |
| Amino Acid Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Sequence (1-letter) | GEPPPGKPADDAGLV |
| Also Known As | Body Protection Compound 157, PL 14736, Pentadecapeptide BPC 157 |
| PubChem CID | 9941957 ↗ |
Identifiers verified against the NIH PubChem compound database. Molecular weights independently recalculated from the molecular formula using IUPAC 2021 standard atomic weights.
How to Read a BPC-157 Certificate of Analysis
A COA is only meaningful if the identifiers on it match the compound you ordered. Four checks, in order.
- 1. Identity โ does the formula match?The COA header should state C62H98N16O22 and a molecular weight near 1419.6 g/mol, with CAS 137525-51-0. A mismatch means you are not looking at a COA for this compound.
- 2. Purity โ HPLC chromatogram, not just a numberA printed “> 99.2%” with no chromatogram is a marketing claim. Demand the actual HPLC trace: a single dominant peak, labelled retention time, and an integration table. Shoulders or unlabelled side peaks are unreported impurities.
- 3. Mass confirmation โ does MS agree with the formula?Mass spectrometry should report an observed mass consistent with the expected 1419.6 g/mol. Peptides are frequently reported as multiply charged ions, so the raw m/z value will be lower than the neutral mass. An unexplained offset is a red flag.
- 4. Provenance โ who signed it, and for which batch?A valid COA names the testing laboratory, carries a batch or lot number that matches your vial label, and is dated. A vendor-produced PDF with no lab identity and no batch number is not third-party evidence.
Full methodology in ourguide to the 5 COA red flags researchers miss, or verify the reconstitution math with thepeptide reconstitution calculator.
Mechanism of Action
BPC-157 is a pentadecapeptide fragment (15 amino acids) derived from human gastric juice protein BPC (Body Protection Compound). It exerts its effects primarily through upregulation of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), driving angiogenesis โ the formation of new blood vessels โ at sites of tissue injury.
Beyond angiogenesis, BPC-157 modulates the nitric oxide (NO) system, interacts with the dopaminergic and serotonergic neurotransmitter pathways, and accelerates fibroblast migration and collagen deposition. In rodent models, it has demonstrated accelerated healing of transected Achilles tendons, gastric ulcers, and ligamentoous injuries. The peptide also exhibits pronounced gastroprotective effects through stabilization of the gut mucosal barrier.
Its short systemic half-life (~4 hours) necessitates daily research administration protocols to maintain steady-state tissue concentrations. Local injection near the site of injury appears to produce higher local tissue levels than systemic administration in animal models.
Research History & Context
BPC-157 was first isolated and characterized at the University of Zagre in the early 1990s by a research group led by Prof. Predrag Sikiriฤ. Early research focused on its gastric cytoprotective properties, leading to its classification as a "Body Protection Compound." Over the subsequent three decades, more than 200 peer-reviewed publications have documented its effects across multiple tissue types and injury models.
The compound has been extensively studied in rodent models of musculosceletal injury, inflammatory bowel disease, and central nervous system trauma. No formal human clinical trials have been completed as of 2026, though case-report literature and anecdotal research data have driven significant interest in the biohacking and regenerative-medicine communities.
Storage & Handling
Lypophilized BPC-157 is stable at -20ยฐC for >24 months. It is one of the more robust peptides in storage; brief room-temperature exposure during shipping does not significantly degrade the compound. Store vials in a dark, dry environment.
After reconstitution with bacteriostatic water, BPC-157 remains stable at 2โ8ยฐC for 21โ28 days. Some research protocols recommend aliquoting the reconstituted solution into sterile single-use vials and freezing at -20ยฐC for extended storage (up to 90 days), though a single freeze-thaw cycle should be observed. Do not refreeze after thawing.
Reconstitution & Research Dosing
For BPC-157, the standard laboratory reconstitution is 2.5 ml BAC water for 5mg vial (200mcg per 0.1ml). A typical research study window uses 250 - 500 mcg / daily.
For a 5mg BPC-157 research vial, the most common protocol is 2.5 ml BAC water, yielding 200 mcg per 0.1 ml (10 IU on a U-100 syringe). For oral/gavage research protocols, reconstitute at higher concentrations (e.g., 1.0 ml BAC water for 5mg) and dilute into the research medium immediately before administration. BPC-157 is stable in acidic environments, which is relevant for gastric-research protocols.
Use the Reconstitution Calculator for exact syringe units →Audited Vendors Stocking BPC-157
Each review checks whether the testing lab is named and whether COAs can be verified at the issuing lab.
Related BPC-157 Research
BPC-157 FAQ
QWhat is the molecular formula of BPC-157?
BPC-157 has the molecular formula C62H98N16O22 and a molecular weight of approximately 1419.6 g/mol. Its CAS registry number is 137525-51-0. It is a 15-residue peptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.
QHow do you verify a BPC-157 Certificate of Analysis?
Check four things in order. First, identity: the COA must state C62H98N16O22 and CAS 137525-51-0. Second, purity: require the actual HPLC chromatogram with retention time and integration table, not just a printed percentage. Third, mass confirmation: the mass spectrometry result must agree with the expected molecular weight of 1419.6 g/mol, allowing for multiply charged ions. Fourth, provenance: the COA must name the testing laboratory and carry a batch number matching your vial label.
QWhat purity should BPC-157 be?
Research-grade BPC-157 should meet a purity target of > 99.2%, confirmed by third-party HPLC analysis rather than a vendor self-declaration. A purity claim without an accompanying chromatogram carries no evidential weight.
QWhat is the half-life of BPC-157?
The reported half-life of BPC-157 is Short (~4 hours systemic). Half-life figures come from published research models and vary with species, route and formulation, so treat them as a reference range rather than a fixed value.
QHow much bacteriostatic water do you add to BPC-157?
The standard reconstitution for BPC-157 is 2.5 ml BAC water for 5mg vial (200mcg per 0.1ml). For a 5mg BPC-157 research vial, the most common protocol is 2.5 ml BAC water, yielding 200 mcg per 0.1 ml (10 IU on a U-100 syringe). For oral/gavage research protocols, reconstitute at higher concentrations (e.g., 1.0 ml BAC water for 5mg) and dilute into the research medium immediately before administration. BPC-157 is stable in acidic environments, which is relevant for gastric-research protocols.
Explore Related Research Compounds
Research Use Only (RUO): BPC-157 is discussed strictly as an in-vitro laboratory research compound. Nothing on this page constitutes human or clinical administration guidance. Always verify purity through independent third-party HPLC/MS analysis before use.